ferulic acid protects pc12 neurons against hypoxia by inhibiting the p-mapks and cox-2 pathways
Authors
abstract
objective(s):hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. here, the protective effects of ferulic acid (fa) on hypoxia-induced neurotoxicity in pc12 cells were evaluated. materials and methods:we investigated the effect of fa on pc12 cells subjected to hypoxia stress, in vitro. results:fa increased cell viability, prevented membrane damage (ldh release), scavenged free radicals, increased superoxide dismutase (sod) activity, and attenuated the elevation of intracellular free ca2+, lipid peroxidation, apoptosis (evaluated by tunel staining) and pge2 production in hypoxia-stressed pc12 cells. mapks were activated during hypoxia. fa reduced p-p38 mapk, caspase-3, and cox-2 activation which correlated well with diminished ldh release in pc12 cells under hypoxia. furthermore, fa reduced lipid peroxidation in pc12 cells subjected to hypoxia. conclusion:taken together, these results indicate that fa antioxidant effects could partly be involved in inhibition of p38 mapk pathway and apoptosis through scavenging ros in hypoxia-stressed pc12 cells.
similar resources
Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways
Objective(s):Hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of ferulic acid (FA) on hypoxia-induced neurotoxicity in PC12 cells were evaluated. Materials and Methods:We investigated the effect of FA on PC12 cells subjected to hypoxia stress, in vitro. Results:FA increased cell viability, prevented membrane damage (LDH r...
full textFerulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways
OBJECTIVES Hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of ferulic acid (FA) on hypoxia-induced neurotoxicity in PC12 cells were evaluated. MATERIALS AND METHODS We investigated the effect of FA on PC12 cells subjected to hypoxia stress, in vitro. RESULTS FA increased cell viability, prevented membrane damage (LDH...
full textHydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury by Inhibiting ROS-Activated ERK1/2 and p38MAPK Signaling Pathways in PC12 Cells
Hydrogen sulfide (H(2)S) has been proposed as a novel neuromodulator and neuroprotective agent. Cobalt chloride (CoCl(2)) is a well-known hypoxia mimetic agent. We have demonstrated that H(2)S protects against CoCl(2)-induced injuries in PC12 cells. However, whether the members of mitogen-activated protein kinases (MAPK), in particular, extracellular signal-regulated kinase1/2(ERK1/2) and p38MA...
full textTiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
Microglial activation and inflammation are associated with progressive neuronal apoptosis in neurodegenerative disorders such as Parkinson's disease (PD). γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system, has recently been shown to play an inhibitory role in the immune system. Tiagabine, a piperidine derivative, enhances GABAergic transmission by i...
full textAndrographolide Protects against Aortic Banding-Induced Experimental Cardiac Hypertrophy by Inhibiting MAPKs Signaling
Despite therapeutic advances, heart failure-related mortality rates remain high. Therefore, understanding the pathophysiological mechanisms involved in the remodeling process is crucial for the development of new therapeutic strategies. Andrographolide (Andr), a botanical compound, has potent cardio-protective effects due to its ability to inhibit mitogen-activated protein kinases (MAPKs). Andr...
full textRensheng Shouwu Protects against Neuronal Injury by Inhibiting the Apoptosis Induced by Hypoxia and Reoxygenation
Rensheng Shouwu Capsule (RSSW) is an approved and patented drug of Traditional Chinese Medicine that has been used for years to treat vascular dementia and neural syndrome related to cerebral-vascular ischemia. However, the underlying mechanism of RSSW remains unclear. Previous studies have indicated that RSSW could significantly reduce cerebral ischemic injury and improve vascular dementia. In...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of basic medical sciencesجلد ۱۸، شماره ۵، صفحات ۴۷۸-۴۸۴
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023